PACSIN1

Across TCGA patient cohorts, PACSIN1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PACSIN1-associated genes across cancer lineages are Lck, mTOR_pS2448, and PCNA. Each is linked with PACSIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PACSIN1-to-partner and partner-to-PACSIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by PACSIN1-low versus PACSIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACSIN1→partner) and Y-score (partner→PACSIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.251	+2.999	.001	.035	3	2
UCEC	mTOR_pS2448 →	-0.143	-2.986	.017	.035	3	2
UCEC	PCNA →	+0.227	+1.906	.008	.016	3	2
UCEC	ATM →	-0.560	-2.415	.002	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+1.001	+3.479	<.001	.002	3	2
COAD	GSK3-a-b →	+0.204	+2.849	.014	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Lck by PACSIN1 expression — UCEC

Explore this box plot interactively →