PACSIN1

Across TCGA cell cohorts, PACSIN1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PACSIN1-associated genes across cancer lineages are SIGLEC5, DMRTB1, and SIGLEC7. Each is linked with PACSIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PACSIN1-to-partner and partner-to-PACSIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by PACSIN1-low versus PACSIN1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACSIN1→partner) and Y-score (partner→PACSIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SIGLEC5 →	+0.227	+2.803	<.001	.003	3	1
LUNG_NSCLC_LUAD	DMRTB1 →	+0.003	+2.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	SIGLEC7 →	+0.039	+3.215	<.001	<.001	3	1
LUNG_NSCLC_LUAD	PABPC1L2A →	+0.015	+2.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TEX46 →	+0.222	+3.624	<.001	.003	2	2
LUNG_NSCLC_LUAD	IQCF3 →	+0.016	+3.228	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SIGLEC5 by PACSIN1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →