PACSIN1

Across TCGA cell cohorts, PACSIN1 mutation is significantly associated with the mutation status of many other genes, with 268 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PACSIN1-associated genes across cancer lineages are OS9, LRRC37B, and PCDHGA12. Each is linked with PACSIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PACSIN1-to-partner and partner-to-PACSIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OS9 grouped by PACSIN1-low versus PACSIN1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACSIN1→partner) and Y-score (partner→PACSIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OS9 →	+5.502	+5.502	.003	.003	1	2
LUNG_SCLC	LRRC37B →	+4.502	+5.066	.007	.007	1	2
LUNG_SCLC	PCDHGA12 →	+5.502	+5.502	.003	.003	1	2
LUNG_NSCLC_LUAD	BPI →	+3.662	+3.000	.007	.007	1	2
LUNG_NSCLC_LUAD	PRG4 →	+3.078	+2.944	.003	.003	1	2
LUNG_NSCLC_LUAD	UTP25 →	+3.662	+3.000	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 268 associations by consensus.

OS9 by PACSIN1 expression — LUNG_SCLC

Explore this box plot interactively →