PACS2

Across TCGA patient cohorts, PACS2 mutation is significantly associated with the RNA expression of many other genes, with 1,976 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PACS2-associated genes across cancer lineages are CCL5, CCL4, and IGKV1D-13. Each is linked with PACS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PACS2-to-partner and partner-to-PACS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL5 grouped by PACS2-low versus PACS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACS2→partner) and Y-score (partner→PACS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL5 →	+1.062	+4.087	<.001	<.001	3	2
UCEC	CCL4 →	+0.617	+1.857	.004	<.001	3	2
UCEC	IGKV1D-13 →	+1.411	+3.229	<.001	<.001	3	2
CESC	RNU6-128P →	+0.334	+5.306	<.001	.006	3	2
CESC	H3P22 →	+0.106	+6.342	<.001	.001	3	2
UCEC	C4orf33 →	+0.415	+1.595	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,976 associations by consensus.

CCL5 by PACS2 expression — UCEC

Explore this box plot interactively →