PACRG

Across TCGA pan-cancer cohorts, PACRG mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PACRG data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PACRG mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PACRG expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where PACRG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.304	1.000	.022	7	view →
UCEC	OS	Median	All	0.761	1.000	.023	2	view →
LSCC	DFS	Tertile	All	1.000	0.612	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PACRG–LUAD (OS)

Open the LUAD breakdown →