PACRG

Across TCGA pan-cancer cohorts, PACRG RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PACRG’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PACRG RNA is repressed in tumor relative to normal tissue. In most cancer types PACRG is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LUAD are the cancer types where PACRG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PACRG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−2.213	<.001	12	view →
THCA	Male	III,IV	−1.445	<.001	10	view →
LUAD	Female	III,IV	−1.794	<.001	9	view →
KIRP	Male	II,III,IV	−1.742	<.001	9	view →
COAD	All	II,III,IV	−0.262	<.001	8	view →
LUSC	Female	All	−1.398	<.001	7	view →
STAD	Male	All	−0.532	<.001	7	view →
BRCA	Female	All	−1.013	<.001	6	view →
HNSC	All	II,III,IV	−0.674	<.001	6	view →
KICH	Female	II,III,IV	+1.945	<.001	5	view →
UCEC	All	All	−1.728	<.001	4	view →
ESCA	All	All	−0.945	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PACRG–KIRC

Open the KIRC breakdown →