PACRG

Across TCGA cell cohorts, PACRG mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PACRG-associated genes across cancer lineages are HOXB1, DAZ2, and RBMY1J. Each is linked with PACRG in more than 1 cancer types. Because this analysis shows association rather than direction, both PACRG-to-partner and partner-to-PACRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HOXB1 grouped by PACRG-low versus PACRG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACRG→partner) and Y-score (partner→PACRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HOXB1 →	+0.023	+3.113	<.001	.004	3	1
LARGE_INTESTINE	DAZ2 →	+0.145	+4.000	.002	<.001	3	1
LARGE_INTESTINE	RBMY1J →	+0.005	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

HOXB1 by PACRG expression — LARGE_INTESTINE

Explore this box plot interactively →