PACRG-AS1

Across TCGA pan-cancer cohorts, PACRG-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated PACRG-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher PACRG-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PACRG-AS1 expression acts as an unfavorable survival marker, although some lineages such as THYM and BLCA show a favorable association.

LGG, THYM, and BLCA are the cancer types where PACRG-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.334	0.544	<.001	48	view →
THYM	DFS	Median	All	1.000	0.638	.001	32	view →
BLCA	OS	Tertile	All	0.708	0.527	.008	31	view →
SKCM	OS	Median	All	0.838	0.735	.002	31	view →
UVM	DFS	Tertile	All	0.796	0.491	.018	30	view →
MESO	OS	Median	All	0.289	0.452	.014	21	view →
LIHC	OS	Median	II,III,IV	0.816	0.634	.002	17	view →
UCS	OS	Tertile	II,III,IV	0.785	0.482	.032	10	view →
PCPG	DFS	Median	All	0.927	0.636	.010	10	view →
LUSC	DFS	Quartile	II,III,IV	0.565	0.764	.008	7	view →
CHOL	OS	Tertile	All	0.837	0.190	.011	6	view →
CESC	OS	Quartile	IV	0.095	0.629	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

PACRG-AS1–LGG (OS)

Open the LGG breakdown →