PACRG-AS1

Across TCGA pan-cancer cohorts, PACRG-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PACRG-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PACRG-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PACRG-AS1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where PACRG-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PACRG-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.226	<.001	12	view →
KIRP	Female	All	−0.220	<.001	9	view →
THCA	All	II,III,IV	−0.102	<.001	9	view →
LUAD	Female	All	−0.237	<.001	8	view →
KICH	Female	II,III,IV	+1.165	<.001	6	view →
BRCA	All	III,IV	−0.198	<.001	6	view →
HNSC	Female	II,III,IV	−0.063	.042	3	view →
UCEC	All	All	−0.258	.018	2	view →
LUSC	All	III,IV	−0.206	.003	2	view →
BLCA	All	All	−0.083	.044	2	view →
CHOL	All	All	+0.315	.027	1	view →
LIHC	Female	All	−0.082	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PACRG-AS1–KIRC

Open the KIRC breakdown →