PACERR

Across TCGA pan-cancer cohorts, PACERR RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PACERR data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PACERR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PACERR expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

KIRC, BLCA, and UVM are the cancer types where PACERR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.534	0.713	<.001	154	view →
BLCA	OS	Tertile	All	0.610	0.317	<.001	82	view →
UVM	DFS	Median	All	0.416	0.747	<.001	68	view →
COAD	DFS	Quartile	All	0.382	0.670	<.001	40	view →
THYM	OS	Median	II,III,IV	0.707	0.960	.002	38	view →
LGG	OS	Median	All	0.863	0.925	<.001	35	view →
HNSC	DFS	Quartile	IV	0.670	0.342	.006	30	view →
THCA	DFS	Quartile	III,IV	0.863	1.000	.010	29	view →
MESO	DFS	Quartile	All	0.154	0.678	.002	24	view →
KIRP	DFS	Median	III,IV	0.120	0.594	.004	23	view →
ACC	DFS	Quartile	II,III,IV	0.069	0.477	.007	16	view →
READ	DFS	Median	III,IV	0.284	0.771	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PACERR–KIRC (OS)

Open the KIRC breakdown →