PACERR

Across TCGA pan-cancer cohorts, PACERR RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PACERR’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PACERR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PACERR is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.

THCA, HNSC, and BRCA are the cancer types where PACERR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PACERR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	+0.856	<.001	11	view →
HNSC	Male	All	+0.272	<.001	10	view →
BRCA	Female	All	−0.173	<.001	6	view →
LUAD	Female	All	+0.645	<.001	4	view →
KIRC	Male	All	+0.117	.028	4	view →
ESCA	Male	All	+0.536	.012	2	view →
PRAD	All	All	−0.510	<.001	2	view →
LUSC	Male	All	+0.268	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PACERR–THCA

Open the THCA breakdown →