Across TCGA patient cohorts, PABPN1L mutation is significantly associated with the RNA expression of many other genes, with 499 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PABPN1L-associated genes across cancer lineages are MTATP6P21, POLR2DP2, and HIKESHI. Each is linked with PABPN1L in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPN1L-to-partner and partner-to-PABPN1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPN1L→partner) and Y-score (partner→PABPN1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTATP6P21 →	+0.441	+3.452	<.001	<.001	3	2
UCEC	POLR2DP2 →	+0.110	+2.845	.004	.005	3	2
UCEC	HIKESHI →	+0.493	+3.459	.003	.005	3	1
UCEC	HIRIP3 →	+0.637	+3.470	.001	.003	3	1
UCEC	RAD17 →	+0.567	+3.459	.004	.005	3	1
UCEC	CWC27 →	+0.657	+3.459	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 499 associations by consensus.

Exploration

PABPN1L survival (RNA) · tumor vs normal (RNA) · all PABPN1L data types