Across TCGA pan-cancer cohorts, PABPN1L RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PABPN1L’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PABPN1L RNA is repressed in tumor relative to normal tissue. In most cancer types PABPN1L is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

LUSC, UCEC, and KIRC are the cancer types where PABPN1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PABPN1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.056	.015	4	view →
UCEC	All	All	−0.049	.017	2	view →
KIRC	Male	All	+0.010	.024	2	view →
LUAD	Male	All	−0.060	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PABPN1L RNA expression & survival · all PABPN1L data types