PABPN1

Across TCGA patient cohorts, PABPN1 mutation is significantly associated with the RNA expression of many other genes, with 925 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PABPN1-associated genes across cancer lineages are RNU6-752P, RN7SL703P, and DAOA. Each is linked with PABPN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PABPN1-to-partner and partner-to-PABPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-752P grouped by PABPN1-low versus PABPN1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPN1→partner) and Y-score (partner→PABPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-752P →	+0.374	+5.797	<.001	.001	3	3
SKCM	RN7SL703P →	+0.212	+6.452	<.001	<.001	3	2
SKCM	DAOA →	+0.043	+4.913	<.001	.002	3	2
UCEC	RN7SKP286 →	+0.047	+4.060	<.001	.006	3	2
UCEC	RN7SKP264 →	+0.259	+2.351	<.001	.003	3	2
UCEC	SEC63P2 →	+0.063	+2.193	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 925 associations by consensus.

RNU6-752P by PABPN1 expression — SKCM

Explore this box plot interactively →