P4HB

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, P4HB mutation is significantly associated with the RNA expression of many other genes, with 3,054 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P4HB-associated genes across cancer lineages are RNA5SP414, MIR569, and RNA5SP416. Each is linked with P4HB in more than 1 cancer types. Because this analysis shows association rather than direction, both P4HB-to-partner and partner-to-P4HB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HB→partner) and Y-score (partner→P4HB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCARNA5SP414 →+0.143+7.471.001.00832
HNSCMIR569 →+0.379+5.182<.001.00732
BRCARNA5SP416 →+0.669+7.471<.001.00832
BRCAMIR2392 →+0.344+7.471<.001.00832
BRCALINC01533 →+0.736+5.378<.001.00632
BLCARNA5SP93 →+0.180+5.632<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,054 associations by consensus.

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