P4HA3

Across TCGA patient cohorts, P4HA3 protein abundance is significantly associated with the RNA expression of many other genes, with 4,931 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible P4HA3-associated genes across cancer lineages are SPARC, SULF1, and ADAM12. Each is linked with P4HA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both P4HA3-to-partner and partner-to-P4HA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, P4HA3 versus SPARC in HNSC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HA3→partner) and Y-score (partner→P4HA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPARC →	+1.458	+1.140	<.001	<.001	3	4
PDAC	SULF1 →	+1.428	+0.937	<.001	.002	3	4
PDAC	ADAM12 →	+1.439	+0.785	.004	.004	3	4
PDAC	MEG8 →	+0.990	+0.606	<.001	.004	3	4
HNSC	RPLP0P2 →	+1.023	+0.702	.002	.002	3	4
PDAC	VCAN →	+1.093	+0.749	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,931 associations by consensus.

P4HA3 vs SPARC — HNSC

Explore this scatter interactively →