P4HA3

Across TCGA pan-cancer cohorts, P4HA3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated P4HA3 data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher P4HA3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated P4HA3 expression acts as an unfavorable survival marker, although some lineages such as DLBC and LIHC show a favorable association.

KIRP, BLCA, and CESC are the cancer types where P4HA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.537	0.837	<.001	109	view →
BLCA	OS	Median	All	0.533	0.688	<.001	98	view →
CESC	DFS	Tertile	All	0.365	0.654	<.001	70	view →
LUSC	DFS	Quartile	II,III,IV	0.453	0.775	<.001	66	view →
UVM	OS	Tertile	III,IV	0.325	0.902	.001	66	view →
KIRC	DFS	Quartile	All	0.537	0.713	.003	54	view →
STAD	OS	Median	All	0.510	0.649	.005	50	view →
THCA	OS	Median	III,IV	0.944	1.000	.003	48	view →
ACC	OS	Tertile	All	0.536	0.956	.002	45	view →
LGG	DFS	Median	All	0.671	0.799	<.001	31	view →
DLBC	DFS	Median	III,IV	1.000	0.457	.003	22	view →
HNSC	OS	Median	II,III,IV	0.607	0.811	.002	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

P4HA3–KIRP (OS)

Open the KIRP breakdown →