P4HA3

Across TCGA patient cohorts, P4HA3 mutation is significantly associated with the RNA expression of many other genes, with 2,332 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P4HA3-associated genes across cancer lineages are IGHVII-15-1, OR8B6P, and MIR4314. Each is linked with P4HA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both P4HA3-to-partner and partner-to-P4HA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHVII-15-1 grouped by P4HA3-low versus P4HA3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HA3→partner) and Y-score (partner→P4HA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	IGHVII-15-1 →	+0.640	+5.309	<.001	.003	3	4
LUSC	OR8B6P →	+0.239	+4.882	<.001	.005	3	4
LIHC	MIR4314 →	+0.738	+6.902	<.001	<.001	3	3
SKCM	CHCHD4P5 →	+0.036	+2.232	<.001	.006	3	3
SKCM	PRAMEF30P →	+0.020	+2.068	.004	.006	3	3
COAD	OR2G2 →	+0.060	+5.003	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,332 associations by consensus.

IGHVII-15-1 by P4HA3 expression — LUSC

Explore this box plot interactively →