P4HA3

Across TCGA patient cohorts, P4HA3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P4HA3-associated genes across cancer lineages are GAPDH, eEF2, and EGFR_pY1068. Each is linked with P4HA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both P4HA3-to-partner and partner-to-P4HA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by P4HA3-low versus P4HA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HA3→partner) and Y-score (partner→P4HA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.530	+2.459	.041	.020	3	2
UCEC	eEF2 →	+0.416	+2.999	.016	.035	3	1
UCEC	EGFR_pY1068 →	-0.322	-3.584	.007	.002	3	1
UCEC	ERK2 →	+0.249	+2.459	.007	.020	3	1
UCEC	PCNA →	+0.283	+2.459	.006	.020	3	1
UCEC	S6_pS240_S244 →	+0.417	+3.000	.033	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

GAPDH by P4HA3 expression — UCEC

Explore this box plot interactively →