P4HA3

Across TCGA cell cohorts, P4HA3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible P4HA3-associated genes across cancer lineages are FTMT, OR6C1, and INSL5. Each is linked with P4HA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both P4HA3-to-partner and partner-to-P4HA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTMT grouped by P4HA3-low versus P4HA3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HA3→partner) and Y-score (partner→P4HA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FTMT →	+0.022	+5.196	<.001	.005	3	1
OVARY	OR6C1 →	+0.013	+5.196	<.001	.005	3	1
SKIN	INSL5 →	+0.053	+4.467	<.001	.004	3	1
SKIN	C3orf22 →	+0.059	+4.415	<.001	.007	3	1
SKIN	C5orf52 →	+0.046	+4.415	<.001	.007	3	1
SKIN	GOLGA6L22 →	+0.005	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FTMT by P4HA3 expression — OVARY

Explore this box plot interactively →