P4HA2-AS1

Across TCGA pan-cancer cohorts, P4HA2-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of P4HA2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where P4HA2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types P4HA2-AS1 is over-expressed in tumor, although a few such as KIRP and LUAD show the opposite, repressed pattern.

KIRP, LUAD, and LUSC are the cancer types where P4HA2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P4HA2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−0.274	.001	10	view →
LUAD	Male	All	−0.273	<.001	7	view →
LUSC	Female	All	−0.380	<.001	6	view →
KIRC	Male	II,III,IV	+0.334	<.001	6	view →
THCA	All	All	+0.188	<.001	6	view →
LIHC	All	All	+0.050	<.001	4	view →
CHOL	All	All	+0.169	.002	3	view →
UCEC	All	All	−0.138	.008	2	view →
PRAD	All	All	−0.103	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

P4HA2-AS1–KIRP

Open the KIRP breakdown →