P4HA1

Across TCGA cell cohorts, P4HA1 mutation is significantly associated with the mutation status of many other genes, with 2,871 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible P4HA1-associated genes across cancer lineages are USP34, DOCK4, and KCNC1. Each is linked with P4HA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both P4HA1-to-partner and partner-to-P4HA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP34 grouped by P4HA1-low versus P4HA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HA1→partner) and Y-score (partner→P4HA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP34 →	+1.478	+3.408	.007	.007	1	4
LARGE_INTESTINE	DOCK4 →	+1.799	+3.769	.002	.002	1	3
BLOOD_Lymphoma	KCNC1 →	+6.014	+6.014	.001	.001	1	3
UPPER_AERODIGESTIVE_TRACT	HECW2 →	+4.392	+4.954	.008	.008	1	3
LARGE_INTESTINE	ITGB7 →	+2.951	+3.793	<.001	<.001	1	3
BLOOD_Lymphoma	SNX27 →	+6.014	+6.014	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,871 associations by consensus.

USP34 by P4HA1 expression — LARGE_INTESTINE

Explore this box plot interactively →