P3R3URF

Across TCGA pan-cancer cohorts, P3R3URF RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of P3R3URF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where P3R3URF RNA is repressed in tumor relative to normal tissue. In most cancer types P3R3URF is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC and BRCA are the cancer types where P3R3URF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P3R3URF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.049	.002	4	view →
BRCA	All	II,III,IV	+0.014	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

P3R3URF–KIRC

Open the KIRC breakdown →