P3H4

Across TCGA patient cohorts, P3H4 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P3H4-associated genes across cancer lineages are MSH6, PRAS40_pT246, and Annexin-1. Each is linked with P3H4 in more than 1 cancer types. Because this analysis shows association rather than direction, both P3H4-to-partner and partner-to-P3H4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by P3H4-low versus P3H4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H4→partner) and Y-score (partner→P3H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.395	-3.000	.038	.037	3	1
UCEC	PRAS40_pT246 →	+0.326	+3.013	<.001	.019	3	1
UCEC	Annexin-1 →	+0.921	+2.827	.002	.035	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.516	+3.000	.036	.037	2	1
UCEC	N-Ras →	-0.168	-2.986	.014	.037	2	1
UCEC	Caspase-8 →	-0.330	-3.000	.023	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MSH6 by P3H4 expression — UCEC

Explore this box plot interactively →