P3H4

Across TCGA pan-cancer cohorts, P3H4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated P3H4 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher P3H4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated P3H4 expression acts as an unfavorable survival marker, although some lineages such as THCA and ESCA show a favorable association.

MESO, BLCA, and KIRC are the cancer types where P3H4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.378	0.703	<.001	123	view →
BLCA	OS	Median	All	0.355	0.518	<.001	104	view →
KIRC	DFS	Quartile	All	0.693	0.890	<.001	98	view →
ACC	DFS	Median	All	0.402	0.755	<.001	89	view →
UVM	DFS	Tertile	All	0.360	0.704	.001	77	view →
KIRP	DFS	Quartile	All	0.536	1.000	.002	65	view →
LGG	DFS	Median	All	0.667	0.810	<.001	53	view →
CHOL	DFS	Tertile	All	0.132	0.657	<.001	27	view →
SARC	OS	Quartile	All	0.651	0.878	<.001	26	view →
CESC	OS	Quartile	All	0.658	0.889	<.001	20	view →
LUAD	DFS	Tertile	All	0.209	0.521	.011	15	view →
TGCT	DFS	Median	All	0.539	0.800	.002	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

P3H4–MESO (OS)

Open the MESO breakdown →