P3H4

Across TCGA cell cohorts, P3H4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,908 significant associations in total. BONE shows the largest number of these associations.

The most reproducible P3H4-associated GO terms across cancer lineages are Collagen biosynthetic process, Heparan sulfate proteoglycan metabolic process, and Cellular response to morphine. Each is linked with P3H4 in more than 11 cancer types. Because this analysis shows association rather than direction, both P3H4-to-partner and partner-to-P3H4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Collagen biosynthetic process grouped by P3H4-low versus P3H4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H4→partner) and Y-score (partner→P3H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Collagen biosynthetic process →	+0.243	+1.217	<.001	<.001	3	12
BONE	Heparan sulfate proteoglycan metabolic process →	+0.137	+1.577	<.001	<.001	3	12
PANCREAS	Cellular response to morphine →	+0.176	+1.016	<.001	.001	3	11
PANCREAS	Cellular response to isoquinoline alkaloid →	+0.176	+1.016	<.001	.001	3	11
BONE	Protein hydroxylation →	+0.102	+1.567	<.001	.001	2	12
BONE	Positive regulation of cell-substrate adhesion →	+0.180	+1.899	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,908 associations by consensus.

Collagen biosynthetic process by P3H4 expression — BONE

Explore this box plot interactively →