P3H3

Across TCGA patient cohorts, P3H3 mutation is significantly associated with the RNA expression of many other genes, with 1,105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P3H3-associated genes across cancer lineages are RN7SL386P, MAP3K8, and TXNL4A. Each is linked with P3H3 in more than 1 cancer types. Because this analysis shows association rather than direction, both P3H3-to-partner and partner-to-P3H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL386P grouped by P3H3-low versus P3H3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H3→partner) and Y-score (partner→P3H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL386P →	+0.094	+2.097	.007	.005	3	2
SKCM	MAP3K8 →	-0.740	-3.440	.008	.005	3	2
COAD	TXNL4A →	+0.473	+3.472	<.001	.002	3	2
SKCM	AKT1 →	+0.496	+2.616	.002	.006	3	2
SKCM	SDHA →	+0.518	+3.341	.005	.005	3	2
UCEC	CD8A →	+0.799	+2.269	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,105 associations by consensus.

RN7SL386P by P3H3 expression — UCEC

Explore this box plot interactively →