P3H3

Across TCGA pan-cancer cohorts, P3H3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of P3H3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where P3H3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types P3H3 is over-expressed in tumor, although a few such as KIRC and UCEC show the opposite, repressed pattern.

LUAD, THCA, and KIRC are the cancer types where P3H3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P3H3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	+1.327	<.001	9	view →
THCA	Female	II,III,IV	+1.199	<.001	9	view →
KIRC	Male	II,III,IV	−0.825	<.001	8	view →
LUSC	All	II,III,IV	+1.325	<.001	7	view →
HNSC	All	All	+1.012	<.001	7	view →
COAD	Female	All	+0.859	<.001	7	view →
UCEC	All	All	−1.793	<.001	6	view →
KICH	All	All	−1.688	<.001	6	view →
BRCA	Female	All	+0.453	<.001	6	view →
CHOL	Female	All	+1.456	.001	5	view →
PRAD	All	All	−1.174	<.001	2	view →
BLCA	Male	IV	−1.650	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

P3H3–LUAD

Open the LUAD breakdown →