P3H3

Across TCGA patient cohorts, P3H3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P3H3-associated genes across cancer lineages are mTOR_pS2448, ATM, and PDK1_pS241. Each is linked with P3H3 in more than 1 cancer types. Because this analysis shows association rather than direction, both P3H3-to-partner and partner-to-P3H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by P3H3-low versus P3H3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H3→partner) and Y-score (partner→P3H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.190	-3.439	.001	.005	3	2
UCEC	ATM →	-0.526	-2.415	.003	.003	3	2
COAD	PDK1_pS241 →	-0.168	-2.313	.027	.035	3	1
COAD	Caspase-7-cleavedD198 →	+0.974	+2.330	.006	.020	3	1
COAD	CDK1_pY15 →	+0.251	+2.188	.016	.034	3	1
COAD	Cyclin-E1 →	+0.225	+2.330	.046	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

mTOR_pS2448 by P3H3 expression — UCEC

Explore this box plot interactively →