P3H3

Across TCGA cell cohorts, P3H3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,348 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible P3H3-associated GO terms across cancer lineages are Collagen biosynthetic process, Action potential propagation, and AMPA glutamate receptor clustering. Each is linked with P3H3 in more than 10 cancer types. Because this analysis shows association rather than direction, both P3H3-to-partner and partner-to-P3H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Collagen biosynthetic process grouped by P3H3-low versus P3H3-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H3→partner) and Y-score (partner→P3H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Collagen biosynthetic process →	+0.293	+1.289	<.001	<.001	3	11
URINARY_TRACT	Action potential propagation →	+1.224	+3.727	<.001	<.001	3	11
URINARY_TRACT	AMPA glutamate receptor clustering →	+1.327	+3.675	<.001	<.001	3	11
URINARY_TRACT	Glutamate receptor clustering →	+1.327	+3.675	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Regulation of blood-brain barrier permeability →	-0.369	-3.305	<.001	<.001	3	10
PANCREAS	Regulation of heart rate by cardiac conduction →	-0.255	-2.155	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,348 associations by consensus.

Collagen biosynthetic process by P3H3 expression — CNS

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