P2RY6

Across TCGA patient cohorts, P2RY6 mutation is significantly associated with the RNA expression of many other genes, with 2,279 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY6-associated genes across cancer lineages are TCP11X3P, ATP6V1D, and GSKIP. Each is linked with P2RY6 in more than 2 cancer types. Because this analysis shows association rather than direction, both P2RY6-to-partner and partner-to-P2RY6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP11X3P grouped by P2RY6-low versus P2RY6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY6→partner) and Y-score (partner→P2RY6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TCP11X3P →	+0.175	+2.158	.008	<.001	3	3
UCEC	ATP6V1D →	+0.438	+3.321	.001	<.001	3	2
UCEC	GSKIP →	+0.563	+2.169	<.001	.003	3	2
UCEC	NCAPG →	+0.990	+3.818	<.001	<.001	3	2
UCEC	ABHD5 →	+0.612	+1.786	<.001	.008	3	2
UCEC	SYT7 →	-0.949	-2.169	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,279 associations by consensus.

TCP11X3P by P2RY6 expression — UCEC

Explore this box plot interactively →