P2RY6

Across TCGA pan-cancer cohorts, P2RY6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of P2RY6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where P2RY6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types P2RY6 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

THCA, KIRC, and LUAD are the cancer types where P2RY6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P2RY6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.985	<.001	11	view →
KIRC	All	All	+0.625	<.001	10	view →
LUAD	Female	III,IV	+2.610	<.001	9	view →
LUSC	Male	All	+1.225	<.001	9	view →
HNSC	All	All	+1.146	<.001	9	view →
STAD	Male	II,III,IV	+1.579	<.001	8	view →
BLCA	All	IV	+1.237	<.001	6	view →
BRCA	All	All	+0.811	<.001	6	view →
KICH	All	All	−0.986	<.001	5	view →
ESCA	All	All	+1.886	.001	4	view →
UCEC	All	III,IV	+1.087	.004	4	view →
LIHC	All	All	+0.466	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

P2RY6–THCA

Open the THCA breakdown →