P2RY6

Across TCGA patient cohorts, P2RY6 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY6-associated genes across cancer lineages are mTOR_pS2448, AMPK_alpha, and PRDX1. Each is linked with P2RY6 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY6-to-partner and partner-to-P2RY6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by P2RY6-low versus P2RY6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY6→partner) and Y-score (partner→P2RY6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.142	-2.302	.021	.034	3	2
UCEC	AMPK_alpha →	-0.168	-2.459	.032	.019	3	2
COAD	PRDX1 →	+0.196	+2.832	.019	.035	3	1
UCEC	EGFR_pY1068 →	-0.254	-1.807	.014	.027	3	1
UCEC	EGFR →	-0.213	-2.973	.001	.035	3	1
UCEC	FoxM1 →	+0.323	+3.000	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

mTOR_pS2448 by P2RY6 expression — UCEC

Explore this box plot interactively →