P2RY6

Across TCGA cell cohorts, P2RY6 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible P2RY6-associated genes across cancer lineages are DDX25, AVP, and OR2W3. Each is linked with P2RY6 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY6-to-partner and partner-to-P2RY6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDX25 grouped by P2RY6-low versus P2RY6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY6→partner) and Y-score (partner→P2RY6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DDX25 →	+0.100	+3.254	<.001	.007	3	1
BLOOD_Lymphoma	AVP →	+0.038	+5.209	<.001	.005	3	1
LARGE_INTESTINE	OR2W3 →	+0.703	+3.355	.008	.007	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DDX25 by P2RY6 expression — LARGE_INTESTINE

Explore this box plot interactively →