P2RY14

Across TCGA patient cohorts, P2RY14 mutation is significantly associated with the RNA expression of many other genes, with 2,328 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY14-associated genes across cancer lineages are HMGB1P35, RNA5SP419, and RNA5SP147. Each is linked with P2RY14 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY14-to-partner and partner-to-P2RY14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P35 grouped by P2RY14-low versus P2RY14-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY14→partner) and Y-score (partner→P2RY14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	HMGB1P35 →	+0.049	+3.466	<.001	.006	3	2
LUSC	RNA5SP419 →	+0.844	+4.780	<.001	.003	3	2
LUSC	RNA5SP147 →	+0.180	+4.584	.002	.004	3	2
LUSC	RNA5SP422 →	+0.762	+4.412	<.001	.006	3	2
UCEC	RNA5SP416 →	+0.677	+2.224	<.001	.002	3	2
LUSC	RNA5SP415 →	+0.806	+4.412	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,328 associations by consensus.

HMGB1P35 by P2RY14 expression — LUSC

Explore this box plot interactively →