P2RY14

Across TCGA pan-cancer cohorts, P2RY14 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of P2RY14’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where P2RY14 RNA is repressed in tumor relative to normal tissue. In most cancer types P2RY14 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and KIRC are the cancer types where P2RY14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P2RY14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−2.750	<.001	11	view →
COAD	Female	III,IV	−2.686	<.001	11	view →
KIRC	Female	All	+1.083	<.001	11	view →
LUSC	Female	II,III,IV	−2.407	<.001	8	view →
LUAD	Female	III,IV	−2.048	<.001	8	view →
STAD	Male	All	−1.426	<.001	8	view →
KIRP	Male	All	−0.712	<.001	8	view →
LIHC	Female	III,IV	+0.402	<.001	7	view →
BRCA	All	III,IV	−1.321	<.001	6	view →
HNSC	Male	All	−0.439	.009	5	view →
KICH	All	All	−0.576	.008	3	view →
READ	Female	All	−2.552	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

P2RY14–BLCA

Open the BLCA breakdown →