P2RY14

Across TCGA patient cohorts, P2RY14 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY14-associated genes across cancer lineages are EGFR, FoxM1, and Heregulin. Each is linked with P2RY14 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY14-to-partner and partner-to-P2RY14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by P2RY14-low versus P2RY14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY14→partner) and Y-score (partner→P2RY14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.146	-1.807	.026	.027	3	1
UCEC	FoxM1 →	+0.262	+1.807	.014	.027	3	1
UCEC	Heregulin →	-0.113	-2.584	.026	.010	3	1
UCEC	Ku80 →	+0.231	+1.820	.017	.016	3	1
UCEC	MEK1 →	+0.368	+2.584	.014	.010	3	1
UCEC	p27_pT198 →	+0.087	+3.000	.048	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR by P2RY14 expression — UCEC

Explore this box plot interactively →