P2RY14

Across TCGA cell cohorts, P2RY14 RNA expression is significantly associated with the go_rna of many other GO terms, with 907 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible P2RY14-associated GO terms across cancer lineages are Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, Negative regulation of mRNA catabolic process, and Regulation of miRNA catabolic process. Each is linked with P2RY14 in more than 4 cancer types. Because this analysis shows association rather than direction, both P2RY14-to-partner and partner-to-P2RY14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway grouped by P2RY14-low versus P2RY14-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY14→partner) and Y-score (partner→P2RY14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway →	+0.093	+0.030	<.001	<.001	3	4
PANCREAS	Negative regulation of mRNA catabolic process →	+0.058	+0.026	<.001	.001	3	4
PANCREAS	Regulation of miRNA catabolic process →	+0.148	+0.022	<.001	.002	3	4
PANCREAS	Negative regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.064	+0.018	<.001	.003	3	4
OVARY	Nuclear envelope organization →	+0.069	+0.013	.002	.009	3	4
OVARY	Cytoplasmic translation →	+0.054	+0.010	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 907 associations by consensus.

Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway by P2RY14 expression — PANCREAS

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