P2RY12

Across TCGA pan-cancer cohorts, P2RY12 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of P2RY12’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where P2RY12 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types P2RY12 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

LUAD are the cancer types where P2RY12 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P2RY12 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−0.774	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

P2RY12–LUAD

Open the LUAD breakdown →