P2RY12

Across TCGA pan-cancer cohorts, P2RY12 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated P2RY12 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher P2RY12 RNA is associated with better overall survival. In most high-consensus cancer types, elevated P2RY12 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

SKCM, LUAD, and CESC are the cancer types where P2RY12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.389	0.287	<.001	101	view →
LUAD	DFS	Median	All	0.733	0.597	<.001	74	view →
CESC	DFS	Median	All	0.639	0.444	.001	70	view →
KIRC	DFS	Quartile	IV	0.800	0.267	<.001	66	view →
HNSC	DFS	Quartile	All	0.450	0.244	.001	51	view →
LAML	DFS	Median	All	0.338	0.587	.001	28	view →
KICH	DFS	Tertile	II,III,IV	0.608	1.000	.002	23	view →
ACC	OS	Quartile	III,IV	0.136	0.848	.006	21	view →
BRCA	OS	Quartile	IV	0.917	0.348	.017	17	view →
LIHC	OS	Tertile	III,IV	0.746	0.366	.004	15	view →
CHOL	DFS	Quartile	All	0.810	0.175	.007	15	view →
LGG	OS	Quartile	All	0.957	0.820	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

P2RY12–SKCM (OS)

Open the SKCM breakdown →