P2RY12

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, P2RY12 protein abundance is significantly associated with the RNA expression of many other genes, with 2,895 significant associations in total. GBM shows the largest number of these associations.

The most reproducible P2RY12-associated genes across cancer lineages are CBLL2, ANXA11, and SSTR1. Each is linked with P2RY12 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY12-to-partner and partner-to-P2RY12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, P2RY12 versus CBLL2 in GBM, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY12→partner) and Y-score (partner→P2RY12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMCBLL2 →-0.513-0.602<.001.00132
GBMANXA11 →+0.491+0.755<.001<.00132
CCRCCSSTR1 →+0.922+0.322<.001.00532
CCRCCGLDN →+1.430+0.322<.001.00532
GBMRYR1 →+0.707+0.708<.001<.00132
GBMLINC01907 →+0.362+0.630<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,895 associations by consensus.

P2RY12 vs CBLL2 — GBM

Per-sample scatter of P2RY12 vs CBLL2 in GBM (Pearson r = -0.31).

Explore this scatter interactively →

Exploration