P2RY12

Across TCGA cell cohorts, P2RY12 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible P2RY12-associated genes across cancer lineages are RNF222 and C10orf53. Each is linked with P2RY12 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY12-to-partner and partner-to-P2RY12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF222 grouped by P2RY12-low versus P2RY12-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY12→partner) and Y-score (partner→P2RY12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RNF222 →	+0.042	+4.256	<.001	.002	3	1
LARGE_INTESTINE	C10orf53 →	+0.012	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

RNF222 by P2RY12 expression — SKIN

Explore this box plot interactively →