P2RY1

Across TCGA patient cohorts, P2RY1 mutation is significantly associated with the RNA expression of many other genes, with 2,053 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY1-associated genes across cancer lineages are MIR4450, LINC01385, and MTND1P6. Each is linked with P2RY1 in more than 2 cancer types. Because this analysis shows association rather than direction, both P2RY1-to-partner and partner-to-P2RY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4450 grouped by P2RY1-low versus P2RY1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY1→partner) and Y-score (partner→P2RY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR4450 →	+0.602	+4.578	.008	.001	3	3
COAD	LINC01385 →	+0.173	+3.338	.002	.007	3	3
LIHC	MTND1P6 →	+0.033	+4.343	<.001	.001	3	3
LIHC	RN7SL134P →	+0.106	+3.282	.001	.004	3	3
SKCM	RPS29P15 →	+0.307	+3.632	<.001	.001	3	3
LUSC	CARS1P1 →	+0.245	+5.517	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,053 associations by consensus.

MIR4450 by P2RY1 expression — LUSC

Explore this box plot interactively →