P2RY1

Across TCGA pan-cancer cohorts, P2RY1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated P2RY1 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher P2RY1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated P2RY1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

UVM, KIRC, and KIRP are the cancer types where P2RY1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.310	0.747	<.001	116	view →
KIRC	OS	Tertile	All	0.852	0.729	<.001	108	view →
KIRP	OS	Median	All	0.887	0.970	<.001	105	view →
LUSC	DFS	Quartile	II,III,IV	0.735	0.482	.001	42	view →
HNSC	DFS	Median	All	0.773	0.641	.001	41	view →
KICH	DFS	Median	All	0.675	1.000	<.001	40	view →
STAD	OS	Tertile	III,IV	0.388	0.750	.012	24	view →
BLCA	OS	Median	III,IV	0.285	0.455	.013	23	view →
LGG	OS	Tertile	All	0.817	0.933	<.001	22	view →
COAD	DFS	Median	II,III,IV	0.718	0.594	.007	16	view →
SKCM	OS	Tertile	IV	0.787	0.186	.007	15	view →
UCEC	OS	Tertile	III,IV	0.784	0.565	.027	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

P2RY1–UVM (DFS)

Open the UVM breakdown →