P2RY1

Across TCGA patient cohorts, P2RY1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY1-associated genes across cancer lineages are EGFR_pY1068, Acetyl-a-Tubulin-Lys40, and MEK1. Each is linked with P2RY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY1-to-partner and partner-to-P2RY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by P2RY1-low versus P2RY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY1→partner) and Y-score (partner→P2RY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.286	-1.678	.002	.023	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.484	+1.678	.013	.023	3	2
UCEC	MEK1 →	+0.435	+2.906	.001	.001	3	2
UCEC	Notch1 →	+0.133	+1.887	.013	.029	3	2
UCEC	PDCD4 →	-0.631	-2.087	<.001	.005	3	2
UCEC	eIF4E →	+0.214	+2.584	.008	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

EGFR_pY1068 by P2RY1 expression — UCEC

Explore this box plot interactively →