P2RX7

Across TCGA pan-cancer cohorts, P2RX7 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated P2RX7 data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher P2RX7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated P2RX7 expression acts as an unfavorable survival marker.

UCEC, ACC, and BLCA are the cancer types where P2RX7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
BLCA	OS	Median	IV	0.153	0.589	.030	6	view →
SKCM	OS	Median	IV	0.179	0.755	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

P2RX7–UCEC (OS)

Open the UCEC breakdown →