P2RX7

Across TCGA pan-cancer cohorts, P2RX7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of P2RX7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where P2RX7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types P2RX7 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, KIRP, and LUSC are the cancer types where P2RX7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P2RX7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+2.499	<.001	12	view →
KIRP	Male	All	+1.426	<.001	11	view →
LUSC	Female	All	−1.349	<.001	8	view →
LUAD	Male	All	−0.863	<.001	8	view →
UCEC	All	All	−1.667	<.001	6	view →
BLCA	All	All	−0.607	.012	5	view →
PAAD	All	All	−1.235	.041	2	view →
STAD	Male	II,III,IV	+0.560	.014	2	view →
COAD	All	All	−0.386	.012	2	view →
PRAD	All	All	−0.265	.039	2	view →
READ	Female	All	−1.351	.040	1	view →
HNSC	Female	All	+0.630	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

P2RX7–KIRC

Open the KIRC breakdown →