P2RX7

Across TCGA patient cohorts, P2RX7 protein abundance is significantly associated with the RNA expression of many other genes, with 9,780 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible P2RX7-associated genes across cancer lineages are PTGDS, FGD2, and CCDC141. Each is linked with P2RX7 in more than 3 cancer types. Because this analysis shows association rather than direction, both P2RX7-to-partner and partner-to-P2RX7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, P2RX7 versus PTGDS in GBM, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX7→partner) and Y-score (partner→P2RX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTGDS →	+0.977	+0.411	<.001	.001	3	4
LSCC	FGD2 →	+0.699	+0.486	<.001	<.001	3	4
LUAD	CCDC141 →	+0.738	+0.541	<.001	<.001	3	4
GBM	ACSM5 →	+0.857	+0.493	<.001	<.001	3	4
BRCA	SNAI3 →	+0.534	+0.443	.003	.001	3	4
LSCC	NCR3 →	+0.618	+0.617	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,780 associations by consensus.

P2RX7 vs PTGDS — GBM

Explore this scatter interactively →