P2RX7

Across TCGA patient cohorts, P2RX7 mutation is significantly associated with the RNA expression of many other genes, with 2,224 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RX7-associated genes across cancer lineages are RNVU1-33, SNRPGP8, and RNU6-961P. Each is linked with P2RX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX7-to-partner and partner-to-P2RX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNVU1-33 grouped by P2RX7-low versus P2RX7-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX7→partner) and Y-score (partner→P2RX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNVU1-33 →	+0.219	+3.849	.003	.006	3	2
LUSC	SNRPGP8 →	+0.327	+4.466	<.001	.002	3	2
UCEC	RNU6-961P →	+0.064	+3.738	.002	.009	3	2
UCEC	RNU6-927P →	+0.183	+2.476	.003	.003	3	2
LUAD	AARS1P1 →	+0.069	+7.930	<.001	.008	3	2
LUAD	RN7SKP46 →	+0.204	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,224 associations by consensus.

RNVU1-33 by P2RX7 expression — LUSC

Explore this box plot interactively →