P2RX7

Across TCGA patient cohorts, P2RX7 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RX7-associated genes across cancer lineages are FoxM1, Notch1, and A-Raf_pS299. Each is linked with P2RX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX7-to-partner and partner-to-P2RX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by P2RX7-low versus P2RX7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX7→partner) and Y-score (partner→P2RX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.205	+2.000	.043	.010	3	2
UCEC	Notch1 →	+0.178	+2.000	.001	.010	3	2
UCEC	A-Raf_pS299 →	-0.185	-2.906	<.001	.001	3	1
UCEC	INPP4B →	-0.290	-3.321	.022	.009	3	1
UCEC	ACVRL1 →	-0.127	-3.887	.018	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.153	-2.115	.020	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FoxM1 by P2RX7 expression — UCEC

Explore this box plot interactively →